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Exploring Quantification Capabilities of FTIR Analysis in Drug Testing: Case Study by TN Scientific

I. Introduction


At TN Scientific, we are committed to being at the forefront of drug testing technologies. In this pursuit, we continually seek to comprehend the capabilities of our tools, notably the Fourier Transform Infrared Spectroscopy (FTIR) machine. One fundamental area of investigation involves the machine's ability to examine and quantify different drug compounds. This study investigates the FTIR's response to different ratios of Levamisole and Lidocaine.


II. Study Background


Drug testing has grown increasingly complex with the diversification of substances. An effective testing procedure is one that accurately identifies and quantifies the components of a sample. FTIR is a widely recognized tool in this process due to its ability to generate distinctive spectral signatures for different compounds.


III. Methodology


Emphasizing the rigors of the drug testing process, we created two unique samples containing different proportions of Levamisole and Lidocaine. Sample A was composed of a 10/90 Levamisole to Lidocaine ratio, while Sample B had an even 50/50 ratio. These samples were analyzed using FTIR to measure the resulting match scores.


IV. Results


The FTIR provided match scores, revealing its response to the different ratios:


Sample A (Levamisole 10%, Lidocaine 90%):

Lidocaine: 884

Levamisole: 676


Sample B (Levamisole 50%, Lidocaine 50%):

Lidocaine: 820

Levamisole: 765


To allow those engaged in this study to delve deeper into the results, the corresponding spectrographs will be included in the appendix of this document due to their large size and intricate detail.


V. Discussion


The FTIR match scores reflect a noticeable variation when the drug volumes change. This response signifies the FTIR's sensitivity to drug proportions within a sample. However, our findings bring to light a crucial point in the application of FTIR for drug testing: its quantification abilities should be interpreted with caution.


VI. Implications for Drug Testing


While FTIR excels in identifying drug components by generating unique spectral signatures, our study suggests that its accuracy in quantifying substance proportions can vary. In the field of drug testing, this indicates that FTIR analysis should be supplemented with other methodologies when precise quantification is crucial.


VII. Conclusion


TN Scientific remains steadfast in its commitment to advancing drug testing technologies. Our study into the capacities and constraints of FTIR for drug quantification illustrates our dedication to this mission. We acknowledge the strengths of FTIR in drug identification and continue to investigate its role in drug quantification to offer the most reliable and accurate solutions in drug testing.

Sample B (Levamisole 50%, Lidocaine 50%):

Sample A (Levamisole 10%, Lidocaine 90%):


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